In a significant breakthrough, doctors at Shenzhen Second People’s Hospital have identified two previously unknown carbapenem resistance genes. This discovery, made by laboratory researchers over the past three years, marks the first time such genes have been found globally. The findings are expected to play a crucial role in combating the growing problem of antibiotic resistance.
The research was part of the Guangdong Science and Technology Project titled "Study on Integrator Gene and Drug Resistance Gene Box in Acinetobacter." Dr. Xu Xiaoping, deputy director of the hospital's laboratory, led the study and successfully identified two new OXA-type genes linked to bacterial resistance. These genes were submitted to global gene banks, and the World Gene Bank has officially named them OXA-116 and OXA-117.
Carbapenem antibiotics are often used as a last resort for treating severe infections such as sepsis, urinary tract infections, pneumonia, skin infections, and central nervous system infections. However, prolonged use can lead to the development of drug-resistant bacteria, rendering these life-saving medications ineffective.
Dr. Xu emphasized that the identification of these new resistance genes is a major step forward in improving the rational use of antibiotics. It not only helps in monitoring and reducing the spread of carbapenem-resistant bacteria but also supports the development of new drugs aimed at overcoming bacterial resistance. This discovery is seen as a vital contribution to global efforts in tackling antibiotic resistance, which remains one of the most pressing public health challenges of our time.
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