Ultrasonic cell pulverizer uses the dispersion effect of ultrasonic waves in the liquid to cause cavitation of the liquid, thereby breaking the solid particles or cell tissue in the liquid.
Ultrasonic Cell Crusher
Ultrasonic waves are an elastic mechanical wave in a matter medium, which is a form of wave, so it can be used to detect physiological and pathological information of the human body, and to diagnose ultrasound. At the same time, it is a form of energy. When a certain dose of ultrasound is transmitted in the living body, the interaction between the two can cause the function and structure of the organism to change, that is, the ultrasonic biological effect. The effects of ultrasound on cells are mainly thermal effects, cavitation effects and mechanical effects. The thermal effect is that when the ultrasound propagates through the medium, the friction hinders the molecular vibration caused by the ultrasound, converting part of the energy into local high heat ( 42-43 °C), because the critical lethal temperature of normal tissue is 45.7 °C, and the tumor tissue ratio Normal tissue sensitivity is high, so at this temperature, the metabolism of tumor cells is impaired, and DNA , RNA , and protein synthesis are affected, thereby killing cancer cells and normal tissues are not affected. The cavitation effect is that under the irradiation of ultrasound, vacuoles are formed in the living body, and mechanical shear pressure and turbulence are generated along with the vibration of the vacuole and its violent explosion, which causes the tumor to hemorrhage and the tissue to collapse and cause necrosis. In addition, when the cavitation bubble bursts, it generates instantaneous high temperature (about 5000 °C) and high pressure (up to 500 × 104Pa ), which can thermally dissociate the water vapor to produce .OH radicals and .H atoms, from .OH radicals and .H. Atomic induced redox reactions can lead to polymer degradation, enzyme inactivation, lipid peroxidation, and cell killing. The mechanical effect is the primary effect of ultrasound. During the propagation process, the medium particles alternately compress and stretch to form a pressure change, causing damage to the cell structure. The strength of the killing effect is closely related to the frequency and intensity of the ultrasound.
Basic principle of ultrasonic cell pulverizer
Ultrasonic cell pulverizer uses the dispersion effect of ultrasonic waves in the liquid to cause cavitation of the liquid, thereby breaking the solid particles or cell tissue in the liquid. The ultrasonic cell pulverizer consists of two parts: an ultrasonic generator and a transducer. The ultrasonic generator converts the utility power into an 18-21 KHz alternating power supply transducer. The zirconium titanate piezoelectric vibrator is the heart of the transducer. It is elastically deformed with the alternating voltage at a frequency of 18-21 kHz, and the transducer is subjected to longitudinal mechanical vibration. The vibration wave generates a cavitation effect by the titanium alloy horn immersed in the biological solution, and the biological particles in the excitation medium vibrate violently.
Ultrasonic cell shredder features
1. Automatic frequency modulation starts without manual adjustment.
2 , there is a temperature protection probe, which can effectively prevent the sample from being damaged due to temperature rise during the crushing process.
3. It can drive external temperature control through “normally open / normally closed†switch according to the feedback signal from the temperature probe.
The work of the unit.
4. The standard probe can be down-converted by MICROTIP below 1/2 †to achieve the micro-sample breakage.
5 , there are different types of probes such as closed cup ( CUP ) and continuous flow ( FILLCELL ) for purchase.
6. There are 96 -well microplates for crushing heads and double-needle probes (guaranteed experimental parallelism).
7. Tracking shows the actual effective power output.
8 , there are nine program memory functions, convenient for users to program and call.
9 , can adjust the "working / intermittent" proportional time cycle pulse type work, the time range from 0.5 seconds to 1
Hour, improve the crushing effect and effectively prevent the temperature rise.
1 0 , with a question menu to protect the micro-probe, can effectively prevent damage to the machine by mistake.
Main purpose of ultrasonic cell pulverizer
Ultrasonic shredders can be used to pulverize animals, plants, bacteria, dental spores or tissues. Disperse rare earth and various inorganic mineral powders.
Ultrasonic pulverizers are ideal for accelerating chemical, biological, and physics reaction rates and accelerating liquid degassing.
The ultrasonic pulverizer can prepare nearly one micron of latex size; homogenize the "immiscible" mixture; polymerize some substances and precipitate other substances.
In summary, the ultrasonic pulverizer can realize various functions of extraction, pulverization, emulsification, homogenization, suspension, variability, aerosol suspension, accelerated desolvation, crystallization and preparation of various biological samples under an electron microscope.
API (Active Pharmaceutical Ingredients)
API is prepared by chemical synthesis, plant extraction or biotechnology, but which can not be taken directly by patients, are generally made into drugs that can be used directly by adding excipients and processing. Currently, China and India are the two major producers of API.
Bilberry Extract, Cranberry Extract, Black Currant Extract, Black Elderberry Extract,
Raspberry Extract, Acerola Cherry Extract, Aronia Chokeberry Extract, Blueberry
Extract, Blackberry Extract, Acai Berry Extract, Lingonberry Extract, Mulberry Extract are our most popular items.
They can be made into capsule, tablet, granule, etc., deeply favored by the pharmaceutical industry and patients.
Xi'an Longze Biotechnology Co., Ltd. , https://www.bestbilberry.com