Lab Supply Powder Peptide Melanotan I 75921-69-6 for Weight Loss

Model NO.: 75921-69-6
Product Name: Mt-1,Melanotan I
Application: Pharmaceutical
Color: White
Appearance: Lyophilized Powder
Trademark: Filter
Transport Package: Plastic Tube
Specification: iu, mg, g, kg
Origin: Shanghai
HS Code: 3004905910
Model NO.: 75921-69-6
Product Name: Mt-1,Melanotan I
Application: Pharmaceutical
Color: White
Appearance: Lyophilized Powder
Trademark: Filter
Transport Package: Plastic Tube
Specification: iu, mg, g, kg
Origin: Shanghai
HS Code: 3004905910
                              Lab Supply Powder Peptide Melanotan I for Weight Loss
 
Description
Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R,MC3-5R). As an analogue of α-MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.

Melanotan-1 Peptide Amino Acid Sequence:
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Molecular formula: C78H111N21O19
Molar Mass: 1646.845
CAS number: 75921-69-6
PubChem: CID 16154396
Synonyms: Melanotan; Melanotan-1; Melanotan I; CUV1647; EPT1647; NDP-MSH; [Nle4, D-Phe7]α-MSH
[Nle4, D-Phe7]-α-MSH Melanotan

The Development of Melanotan 1

The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona. During the course of study aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects whilst possessing an extended half-life for functional therapeutic utilization. The researchers, headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule "Melanotan" (later Melanotan-1).

Melanotan-1 Mechanism of Action - How it Works!

Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.

Our process:
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of producs and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Our advantages:
1. Quality:
Our company is a professional production of hormone intermediates for many years, our products have exported to Germany,Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, you can trust us.
And we are the manufactory, so no problem for us to control the quality.
2.Payment method: Western Union,TT.
3.Service: Best service with after-sales service to all clients.
4.Delivery:
Sample Order :Package will be shipped with 3days after payment. We can send it via UP, EMS, HK Air Post, DHL or othermethod. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.

Other Peptide Our Lab Supply:

Product

Purity

CAS No.

Abarelix Acetate

98%

183552-38-7

Alarelin Acetate

98%

79561-22-1

Angiotensin Acetate

98%

58-49-1

Angiotensin II

98%

 68521-88-0

Antide Acetate

98%

112568-12-4

Argpressin Acetate

98%

113-79-1

Argreline Acetate

98%

 616204-22-9

Atosiban Acetate

98%

90779-69-4

Aviptadil Acetate

98%

40077-57-4

Bate-Amyloid(1-42)human

95%

107761-42-2

Bivalirudin Trifluoroacetate

98%

128270-60-0

Buserelin acetate

98%

57982-77-1

Calcitonin

 

9007/12/9

Carbetocin Acetate

98%

37025-55-1

Carperitide

98%

 89213-87-6

Cecropin B

98%

 

Cetrorelix Acetate

98%

130143-01-0

Cetrorelix Acetate

98%

130143-01-0

CJC-1295

98%

 863288-34-0

Copper Peptide(GHK-Cu)

98%

49557-75-7

CRF (human, rat) Acetate

98%

86784-80-7

CRF (ovine) Trifluoroacetate

98%

79804-71-0

Deslorelin Acetate

98%

57773-65-6

Desmopressin Acetate  

98%

16679-58-6

Dynorphin A (1-13) Acetate  

98%

72957-38-1

Elcatonin Acetate

98%

60731-46-6

Eledoisin Acetate

98%

69-25-0

Endothelin-1 Acetate

98%

117399-94-7

Enfuvirtide Acetate (T-20)

95%

159519-65-0

Eptifibatide Acetate

98%

148031-34-9/188627-80-7

Exenatide Acetate

98%

141732-76-5

Felypressin Acetate

98%

56-59-7

Fertirelin Acetate

98%

38234-21-8

Ganirelix acetate

98%

123246-29-7

GHRP-2 Acetate

98%

158861-67-7

GHRP-6 Acetate

98%

87616-84-0

Glatiramer Acetate

99%

147245-92-9

GLP(7-36)

98%

107444-51-9

GLP-1 (7-37) Acetate

98%

106612-94-6
Lab Supply Powder Peptide Melanotan I 75921-69-6 for Weight Loss

Lab Supply Powder Peptide Melanotan I 75921-69-6 for Weight Loss
                                Lab Supply Powder Peptide Melanotan I for Weight Loss
 
Description
Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R,MC3-5R). As an analogue of α-MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.

Melanotan-1 Peptide Amino Acid Sequence:
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Molecular formula: C78H111N21O19
Molar Mass: 1646.845
CAS number: 75921-69-6
PubChem: CID 16154396
Synonyms: Melanotan; Melanotan-1; Melanotan I; CUV1647; EPT1647; NDP-MSH; [Nle4, D-Phe7]α-MSH
[Nle4, D-Phe7]-α-MSH Melanotan

The Development of Melanotan 1

The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona. During the course of study aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects whilst possessing an extended half-life for functional therapeutic utilization. The researchers, headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule "Melanotan" (later Melanotan-1).

Melanotan-1 Mechanism of Action - How it Works!

Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.

Our process:
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of producs and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Our advantages:
1. Quality:
Our company is a professional production of hormone intermediates for many years, our products have exported to Germany,Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, you can trust us.
And we are the manufactory, so no problem for us to control the quality.
2.Payment method: Western Union,TT.
3.Service: Best service with after-sales service to all clients.
4.Delivery:
Sample Order :Package will be shipped with 3days after payment. We can send it via UP, EMS, HK Air Post, DHL or othermethod. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.

Other Peptide Our Lab Supply:

Product

Purity

CAS No.

Abarelix Acetate

98%

183552-38-7

Alarelin Acetate

98%

79561-22-1

Angiotensin Acetate

98%

58-49-1

Angiotensin II

98%

 68521-88-0

Antide Acetate

98%

112568-12-4

Argpressin Acetate

98%

113-79-1

Argreline Acetate

98%

 616204-22-9

Atosiban Acetate

98%

90779-69-4

Aviptadil Acetate

98%

40077-57-4

Bate-Amyloid(1-42)human

95%

107761-42-2

Bivalirudin Trifluoroacetate

98%

128270-60-0

Buserelin acetate

98%

57982-77-1

Calcitonin

 

9007/12/9

Carbetocin Acetate

98%

37025-55-1

Carperitide

98%

 89213-87-6

Cecropin B

98%

 

Cetrorelix Acetate

98%

130143-01-0

Cetrorelix Acetate

98%

130143-01-0

CJC-1295

98%

 863288-34-0

Copper Peptide(GHK-Cu)

98%

49557-75-7

CRF (human, rat) Acetate

98%

86784-80-7

CRF (ovine) Trifluoroacetate

98%

79804-71-0

Deslorelin Acetate

98%

57773-65-6

Desmopressin Acetate  

98%

16679-58-6

Dynorphin A (1-13) Acetate  

98%

72957-38-1

Elcatonin Acetate

98%

60731-46-6

Eledoisin Acetate

98%

69-25-0

Endothelin-1 Acetate

98%

117399-94-7

Enfuvirtide Acetate (T-20)

95%

159519-65-0

Eptifibatide Acetate

98%

148031-34-9/188627-80-7

Exenatide Acetate

98%

141732-76-5

Felypressin Acetate

98%

56-59-7

Fertirelin Acetate

98%

38234-21-8

Ganirelix acetate

98%

123246-29-7

GHRP-2 Acetate

98%

158861-67-7

GHRP-6 Acetate

98%

87616-84-0

Glatiramer Acetate

99%

147245-92-9

GLP(7-36)

98%

107444-51-9

GLP-1 (7-37) Acetate

98%

106612-94-6
Lab Supply Powder Peptide Melanotan I 75921-69-6 for Weight Loss

Lab Supply Powder Peptide Melanotan I 75921-69-6 for Weight Loss
 

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