Release date: 2007-09-26
Beauty cultures the pulmonary valve implanted in children According to the Science and Technology Daily, Boston Children's Hospital scientists in the "Circulation" journal claimed that they have found a way to use the patient's own cells to cultivate fresh in the laboratory. Growing lung valve. The study was funded by the American Heart Association and the Cambridge Medical Integration and Innovation Technology Center, and the results provide the greatest medical assistance to children who need artificial heart valve surgery.
Pulmonary valves in the human body provide one-way blood flow from the right ventricle of the heart to the pulmonary arteries. Because the heart valve of patients with valvular disease can not open and close normally, or the extent of opening is not enough, or can not be completely closed when closed, normal blood circulation cannot be guaranteed. In the treatment of valvular disease, the artificial heart valve is usually used to replace the problematic heart valve. The prosthetic heart valve has a natural heart valve function, and the heart can be implanted instead of the heart valve, including the aortic valve, pulmonary valve, tricuspid valve and mitral valve, so that the blood flows in one direction.
However, after the artificial heart valve replacement surgery, the infant or child needs to perform several repeated operations during the growth process, because the artificial valve placement in the operation must be changed to be larger as the child grows and develops. Wiener Salles, a researcher at the Boston Children's Hospital for Cardiac Surgery, said: "The heart valve is a complex organ that must be synchronized, resistant to stress, soft and elastic. We hope to be in the child's body. Once planted, it can be done once and for all, instead of having to undergo multiple heart valve surgeries during the growth process.
In this study, scientists first isolated endothelial progenitor cells from experimental animals and then "sowed" them into biodegradable molds in the shape of small valves.
Different protein matrices and growth factors were used in the experiment, and the pulmonary valve was finally produced in the laboratory and the appropriate functional requirements were achieved. Experts say that this living and growing heart valve can grow with children in the body.
Later, Salew exposes the valve to the mechanical pressure of the bioreactor to improve the function of the valve. In addition, she uses a "heart gel" that is rich in soft substances in the composition of the matrix and growth factors to stimulate the cells to differentiate into their own heart valves. Sales said: "The next step will be to plant live valves into animals."
At present, Sales and colleagues have reconstructed a part of the pulmonary artery through bioengineering techniques using small tissues in goats.
Sales has a confident outlook that bioengineering technology can be used to create "live blood vessels" for adults with arteriosclerosis.
Source: Technology Daily
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