Scientists have found "natural analogues" of metformin and rapamycin

Scientists have found "natural analogues" of metformin and rapamycin

December 04, 2017 Source: Bio-Exploration

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Metformin is the most widely used type 2 diabetes drug. Rapamycin is a common organ transplant anti-rejection drug, both of which have been shown to exhibit significant anti-aging and anti-cancer effects in a variety of animal models. It is named after the "medicine". Recently, an international team of scientists brought a related new result: they identified a variety of natural analogues of metformin and rapamycin.

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In a study published in Aging on Nov. 15, in order to identify natural compounds that mimic the effects of metformin and rapamycin while freeing them from side effects, scientists used deep learning neural networks (deep-learning). Neural network) describes the similarities in safety, gene and pathway-level between more than 800 natural compounds and metformin and rapamycin.

Finally, the study identified a number of previously unreported metformin and rapamycin analogs. Among them, allantoin and ginsenoside were identified as "strong mimetics" of metformin; epigallocatechin gallate and isoliquiritigenin were identified It is a "strong analog" of rapamycin; at the same time, a substance called withaferin A was identified as a common "strong analog" of metformin and rapamycin; in addition, their analysis identified four previous An unexplored natural compound that is a fairly strong analog of rapamycin.

Image source: Aging

Franco Cortese, who participated in the study, believes that the study is important, not only because of the identification of novel candidate analogues of metformin and rapamycin, but also because of the research that demonstrates a particularly powerful screening method. This method can be used to identify novel, safe analogs of other known anticancer drugs or drugs (and compounds) that prolong their longevity.

It is reported that earlier this year, researchers launched Young.AI. This is a complex system that “uses recent research advances to conduct deep learning and track various aging biomarkers”. One of their goals is to identify combinations of molecules that give the desired results.

Dr. Alexey Moskalev, co-author and first author of the paper, said: "Aging is not considered a disease. We can use strong substances from natural sources to delay aging and affect the key mechanisms of aging at the molecular and cellular levels."

Reference materials:

1)Scientists find natural mimetics of anti-cancer, anti-aging drugs metformin and rapamycin

2)Towards natural mimetics of metformin and rapamycin

Original title: Scientists have found "natural medicine" "natural analogues" of metformin and rapamycin

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