In the process of fighting against diseases for thousands of years, our working people have gradually accumulated a wealth of medical knowledge through practice and continuous understanding. Due to the unsuccessful literature in the ancient times, this knowledge can only be dictated by the teacher. Later, with the words, it was gradually recorded and medical books appeared. These books serve to summarize the experience of previous people and facilitate their dissemination and promotion. China's medical science has a history of thousands of years. It is a very rich experience of the Chinese people's long-term struggle against diseases. The small laboratory superfine pulverizer has made tremendous contributions to the prosperity of the Chinese nation. Chinese medicine pulverization is an operation process in which a large piece of Chinese medicine solid matter is broken into appropriate fineness by mechanical force. Ultra-fine pulverization in the laboratory is to use the laboratory ultra-fine pulverizer to superfine the material. The main purpose of pulverization is to increase the surface area of ​​the drug and promote drug dissolution. It is beneficial to prepare various pharmaceutical dosage forms. Accelerate the dissolution of active ingredients in the medicine. Easy to formulate, take and exert efficacy. It is convenient for drying and storage of fresh herbs. The degree of pulverization and the principle of pulverization are the degree of pulverization of the solid drug. Often expressed as the ratio of the average diameter (d) of the unpulverized drug to the average diameter (d1) of the pulverized drug, that is, n = d / d1 The principle of pulverization is as follows: The drug should not be excessively pulverized to achieve the desired The degree of comminution can be. To save energy and reduce drug losses during the crushing process. During the comminution process, the components and pharmacological effects of the drug should be kept as much as possible. The medicinal part of Chinese herbal medicines must be smashed and applied. For parts that are difficult to smash, such as veins or fibers, should not be discarded at will, small laboratory superfine pulverizer to avoid loss of active ingredients or relatively increase the active ingredient content of the drug. When sterilizing toxic drugs or stimulating drugs, attention should be paid to labor protection to avoid poisoning. When smashing flammable and explosive drugs, pay attention to fire and explosion protection. Plant herbs should be as dry as possible before crushing. The basic principle of pulverization The formation of objects depends on the cohesion between molecules. The laboratory superfine pulverizer exhibits different hardness and properties due to the difference in cohesion. Therefore, the pulverization process is to partially destroy the cohesive force between the molecules by means of external forces. To achieve the process of crushing purposes. The difficulty of comminution of drugs depends mainly on the structure and properties of the substance, but it is also closely related to the size of the external force. The external forces of various pulverizing machines acting on the pulverized material are of the following types: cutting, squeezing, grinding, impacting, splitting, tearing, and boring. According to the nature of the drug, different types of crushing machinery with external force can be used to obtain the expected crushing effect. In recent years, the newly developed laboratory ultra-fine pulverization and ultra-fine extraction and wall-breaking technology have brought new opportunities for the development of traditional Chinese medicine. In the ultra-fine pulverization of small Chinese medicine experiments, the Chinese herbal medicine was crushed to the level of broken wall by the ultrafine pulverizer. It further improves the absorption of Chinese herbal medicines and improves the taste of Chinese herbal medicines. The value of Chinese herbal medicines after ultra-fine extraction is several times or even tens of times higher than the raw materials of Chinese herbal medicines, due to the relative price of small superfine pulverizers. Low, small footprint, easy to use and easy to operate, so that the majority of Chinese herbalists and Chinese herbal medicine research and development units are favored. As the pioneer in the small laboratory Chinese herbal medicine superfine pulverizer, Beijing Yanshan Zhengde Machinery Equipment Co., Ltd. has been committed to the development of ultra-micro extraction technology. We have introduced the domestic Zui advanced laboratory superfine pulverizer production technology from Taiwan. The groping research finally developed the first mechanical test superfine pulverizer in the mainland. The machine overcomes the shortcomings of high machine cost and imperfect design in Taiwan, and provides a collection of scientific research and production for the vast number of pharmacists and scientific research units in mainland China. One small superfine pulverizer, which has been sold well in China for many years, has made great contributions to China's traditional Chinese medicine extraction industry, and also provided zui economically applicable products and new development opportunities for the development of Chinese medicine industry.
The ultra-fine pulverization technology is based on the traditional smashing technology, and the concept of smashing is greatly extended.
At present, there are mainly the following types of ultrafine grinding equipment:
1. Vibration grinding mill;
2. Mechanical shearing mill;
3. Low temperature physical superfine pulverizer;
4, air jet mill;
Among the above superfine grinding machinery, the jet mill is divided into five types:
1. Horizontal disc type airflow pulverizer
2, circulating tube airflow mill
3, spray reverse flow pulverizer
4, impact plate target airflow pulverizer
5, fluidized bed airflow pulverizer
The airflow pulverizer and the low-temperature physical ultrafine pulverizer have realized industrial production and application, and are widely used. Among them, the low-temperature physical ultrafine pulverizer is widely used in Chinese medicine, precious medicinal materials (such as pearl, ganoderma lucidum spore powder) and other traditional Chinese medicines. In the field, the jet mill is applied in a fluidized bed type air flow ultrafine pulverizer. Of course, when selecting the pulverization method, it depends on the nature of the pulverized material and the degree of comminution required.
Ultrafine pulverization technology plays an extremely important role in promoting the modernization of traditional Chinese medicine, but many of the problems still to be solved by micronized Chinese medicine are not to be ignored. At present, the complete set of research on superfine pulverization technology is not accurate enough, evaluation indicators and clinical verification are not clear enough. It is still to be studied in the application of the pulverization particle size and the extraction of different types of medicinal materials for different types of medicinal materials, and the application of different medicinal materials and particle sedimentation and gelatinization. Some powerful companies engaged in the research and production of ultrafine pulverizer equipment have begun to study and formulate specifications in this area. Now, the specifications for the use of YS series small superfine pulverizers, which have an absolute advantage in the field of small and medium-sized Chinese medicine superfine pulverizers, have been obtained. The recognition of the Chinese medicine industry. It is believed that with the development of science and technology and the intensity of basic research, it is believed that these problems faced by ultrafine grinding technology in this field will be solved.
In short, micronization is one of the effective means to improve the solubility and bioavailability of traditional Chinese medicine. With the continuous improvement and development of measurement technology and pulverization theory, if it can solve the basic problems of preparation engineering research, micro-powder stability and screening and determination of micro-powder size, the ultra-fine pulverizer equipment will further promote its Application of Chinese Herbal Pieces and Prescriptions. It is conducive to improving the competitiveness of Chinese medicine in the international pharmaceutical market.
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